Background and aims: The impact of statin on dementia risk reduction has been a subject of debate over the last decade, but the evidence remains inconclusive. Therefore, we performed a meta-analysis of relevant observational studies to quantify the magnitude of the association between statin therapy and the risk of dementia Individuals of 50 years and older who were prescribed statins had a substantially lowered risk of developing dementia, independent of the presence or absence of untreated hyperlipidaemia, or exposure to non-statin LLAs. The available data do not distinguish between Alzheimer's disease and other forms of dementia
In this large, prospective cohort study, statin use was not associated with incident dementia, mild cognitive impairment, or cognitive decline. No differences were found in any of the primary outcomes between users of hydrophilic versus lipophilic statins Two epidemiologic studies demonstrated a lower risk of dementia in statin users. Statin's beneficial effects accrue to specific sub-groups, such as patients under age 80, and women. Similarly, the use of statins in mid-life seemed to reduce AD and dementia in later life The researchers found that of 300 older adults with mildly impaired thinking and memory, those using lipophilic statins were more likely to develop dementia over the next eight years. Lipophilic statins include such widely used medications as simvastatin (Zocor), atorvastatin (Lipitor) and lovastatin (Altoprev)
According to the research of Dr. Golomb, nerve problems are a common side effect from statin use; patients who use statins for two or more years are at a 4- to 14-fold increased risk of developing idiopathic polyneuropathy compared to controls. 12 She reports that in many cases, patients told her they had complained to their doctors about. In particular, lipophilic and high-potency statins were associated with lower risk of dementia. Statin exposure duration was inversely related to the risk of dementia (P < .001 for the trend). No significant effect modification for the relationship between statin use and the risk of dementia was found for either age or sex Statins have been convincingly shown to reduce the risk of atherosclerotic heart disease and ischemic stroke. 1 In addition to their cardiovascular benefits, statins appear modestly to reduce the risk for developing Alzheimer's dementia. Evidence for this effect is not consistent The researchers found that of 300 older adults with mildly impaired thinking and memory, those using lipophilic statins were more likely to develop dementia over the next eight years. Lipophilic..
.849, 95% CI = 0.787-0.916, p = 0.000), AD (k = 14, aRR = 0.719, 95%.. It has been suggested that high levels of cholesterol in the serum (part of the blood) may increase the risk of dementia and that treatment with cholesterol-lowering medicines such as statins may reduce the risk of dementia Numerical counts indicate the number of patients alive without dementia at the corresponding time. Results show increasing incidence of dementia with time, particularly after a concussion, with reduction in risk associated with statin use. The patients with ankle sprain show minimal healthy-user bias. Figure 2
The primary outcomes were risk of all-caused dementia, AD, VaD, and MCI considering statins use as the exposure. Pooled estimates between statins use and dementia were calculated by using fully adjusted RRs (aRRs) provide in each publication (further details in meta-analysis section) Statin drugs are commonly prescribed to lower cholesterol and the risk of heart attack and stroke. The new study hopes to show that statins also help reduce the risk of dementia. The research might also help doctors determine whether taking statins after 75 is necessary for people who don't have heart disease ARTICLES Articles Statins and the risk of dementia H Jick, G L Zornberg, S S Jick, S Seshadri, D A Drachman Summary Introduction Cognitive impairment in elderly people, once called Background Dementia affects an estimated 10% of the senile dementia, is now known to be a heterogeneous population older than 65 years Worldwide, statins are the most prescribed cholesterol-lowering medication and recent data suggest that 27.9% of adults aged 40 years old or older are on statin therapy. 14 In 2012-2013, 39.2 million individuals—accounting for 221 million prescriptions—were using statins, generating $16.9 billion in U.S. sales. 24 Multiple studies report. Based on some early studies, the Food and Drug Administration (FDA) added a warning on statin drug labels that they may cause memory loss and confusion in some people.  This warning led to fears that statin drugs might increase the risk of dementia and Alzheimer's disease, which is the most common type of dementia.  However, more recent research has flipped that warning around
.7 years of follow-up, researchers found 566 incident cases of dementia (including probable Alzheimer's disease and mixed presentations). Compared with no statin use, statin use was not associated with risk of all-cause dementia, probable Alzheimer's disease or mixed presentations of dementia Dementia was defined as those with primary diagnostic dementia codes such as F00‐F03, G30, G31.1, G31.9 or G31.82. Cox proportional hazards regression models were adopted after stepwise adjustment for confounders to investigate the prospective association between statin exposure and dementia risk. Result A dose of statins limits the increased risk of dementia after a concussion, study finds. Researchers at the University of Toronto studied 30,000 elderly people who had been diagnosed with concussio A new study has found that people 55 and older who took strong anticholinergic medications daily for three years or more had a 50% increased risk of dementia Nearly half of women who take statins eventually develop diabetes, a disease which greatly increases the risk for dementia. But she certainly knows that cholesterol-lowering drugs can cause memory loss since this well-established side effect is listed on the label of every prescription bottle
Lipophilic statins were shown to be associated with an increased risk of dementia exclusively in those people. In that group, 24 percent of lipophilic statin users acquired dementia during the next eight years, compared to 10% of non-statin users and 11% of hydrophilic statin users High total cholesterol lowers the risk of dementia in the elderly. However, drugs that lower cholesterol can lead to memory loss. Every prescription bottle of statin contains this warning. Statin Side Effects The use of statins in late life is unlikely to reduce the risk of dementia. Although some meta-analyses of observational studies suggest that statins may lower the risk of dementia, they are based on studies with varied design and a high risk of unintentional biases .An Alzrisk.org systematic review funded by the Alzheimer's Drug Discovery Foundation concluded that statin use late in life is. It turned out that lipophilic statins were linked to higher dementia risk only among those individuals. In that group, 24% of lipophilic statin users developed dementia over the next eight years, versus 10% of people not using any statin and 11% of hydrophilic statin users. In addition, brain scans revealed certain changes linked to dementia. In other words, according to the University of California at Los Angeles authors, taking lipophilic statins—which include atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin, and pitavastatin—appears to more than double those patients' risk of developing dementia compared with those who do not take statins
Statins and the Risk of Dementia. Source: Jick H, et al. Lancet. 2000;356:1627-1631. Cognitive impairment in elderly people, also known as senile dementia, is a heterogeneous condition that in most cases has pathological and clinical features consistent with Alzheimer's disease (AD). 1 There is evidence to suggest a relationship between lipids and vascular changes involving the brain in. Fast-Tracking Development of Dementia. According to project head, Prasanna Padmanabham, of statins and condition in molecular and medical pharmacology student research program at the University of. The increased dementia risk with statin use at lower baseline cognition was attributable mainly to the increased risk for Alzheimer's disease (AD), Zhou and colleagues reported in the Journal of.
Studies on How High Levels of Cholesterol can Increase Dementia Risk. One of the factors that can increase a person's risk of developing dementia is high cholesterol. A neurology study borrowing insights from Niemann Pick-C disease and Down's syndrome stated that high cholesterol disrupts the process of cell division WACO, TX — The PREVENTABLE study aims to be the largest study in older adults to help lower the risk of Alzheimer's and dementia using a common drug called a statin. Statins are usually used for.
Statin use reduces dementia risk after concussion in seniors. May 21, 2019. Statins not associated with memory or cognition decline in elderly, may be protective in some patients In addition to lowering cholesterol, statins use has been suggested to have a neuroprotective effect. 4-7 Prior studies reported the potential mechanisms for neuroprotective effect of statins to reduce the risk of dementia including (1) lowering the cholesterol level, (2) decreasing cardiovascular risk factors, (3) reducing the deposition of β.
A higher exposure to statins (measured by accumulated dose, mean daily dose, number of days of taking a statin, or % of days taking a statin) was associated with a lower risk of dementia. The use of potent statins (atorvastatin, rosuvastatin) was associated with a lower risk of dementia than the use of less potent statins Statins have multiple potential effects that may impact the development of dementia, such as lowering amyloid levels.28, 29, 30 However, the clinical relevance of lowering APP and Aβ remains unknown, because cognitive function may not be dependent on Aβ levels. 31 Observational studies have suggested a reduced risk of AD in those treated with. Bettermann K, Arnold AM, Williamson J, et al. Statins, risk of dementia, and cognitive function: secondary analysis of the Ginkgo Evaluation of Memory Study. J Stroke Cerebrovasc Dis Studying statins and dementia demands looking into suitable clinical trials that can either support or refute the claim that statins are beneficial for reducing the risk of dementia. There are multiple clinical trials in medical databases that compare administering statin as a pretend medicine or placebo to individuals with normal cognitive. Statins and memory loss. Statins are one of the most commonly prescribed drugs for high cholesterol in the United States. However, recently there have been concerns over their side effects
The adjusted relative risk for those prescribed statins was 0.29 (0.13-0.63; p=0.002). INTERPRETATION: Individuals of 50 years and older who were prescribed statins had a substantially lowered risk of developing dementia, independent of the presence or absence of untreated hyperlipidaemia, or exposure to nonstatin LLAs REALITY: Statins can increase the risk of developing diabetes by about 30 percent in people already at risk for the disease, 2018, researchers found that statin users without baseline cognitive problems had between a 15 and 26 percent reduced risk of developing dementia and mild cognitive dysfunction Statins could reduce risk of vascular-type dementia that has lesser amyloid, tau neuropathology. The incubation period for the development of brain pathology, i.e. amyloid plaques and neurofibrillary tangles (NFTs), for example, to cognitive decline, MCI and dementia is very long, perhaps as much as 20 years or more If statins are protective, one reason may be their cardiovascular benefits: They cut bad cholesterol and help prevent fatty plaques from clogging arteries that supply the brain. But other types of cholesterol medications have not been tied to lower dementia risk, Berlau noted, which hints at something special about statins
cases of incident dementia (104 with AD) among 3308 survivors at risk. Statin use at baseline did not predict incidence of dementia or AD (adjusted hazard ratio for dementia, 1.19; 95% confidence interval, 0.53-2.34; ad-justed hazard ratio for AD, 1.19; 95% confidence inter-val,0.35-2.96),nordidstatinuseatfollow-up(adjuste Statins side effects: Can taking the drug increase your risk of dementia? Expert weighs in STATINS side effects are known to cause muscle weakness, sleep problems and dizziness but could it be. Statins, Concussions and Dementia Risk: What the Study Found. The observational study analyzed nearly 30,000 people over the age of 65 who had been diagnosed with a concussion between 1993 and 2013. Researchers excluded patients with a prior diagnosis of dementia or delirium
Statins and the Risk of Dementia. Bhavin Jankharia: Jun 23: 3: This thread is only visible to paying subscribers of Matka Medicine. Subscribe to view →. . Statins use was associated with dementia risk decrement (relevant risk: 0.85) / Adherence to Statins Use and Risk of Dementia among Patients with Diabetes and Comorbid Hyperlipidemia. In: Inquiry : a journal of medical care organization, provision and financing. 2021 ; Vol. 58. pp. 469580211019201 In patients with mild cognitive impairment, taking lipophilic statins more than doubles their risk of developing dementia compared to those who do not take statins. According to research presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting, PET scans of lipophilic statin users revealed a highly significant.
Statin use was inversely associated with prevalence of dementia (adjusted odds ratio, 0.44; 95% confidence interval, 0.17-0.94). Three years later, we identified 185 cases of incident dementia (104 with AD) among 3308 survivors at risk FDG-PET shows lipophilic statin users at higher risk of dementia By Will Morton, AuntMinnie.com staff writer. June 15, 2021-- FDG-PET scans showed patients taking lipophilic statins may have more than double the risk of converting to dementia over eight years of follow-up compared with those not taking statins, according to a presentation on June 14 at the Society of Nuclear Medicine and. In patients with mild cognitive impairment, taking lipophilic statins more than doubles their risk of developing dementia compared to those who do not take statins. According to research presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting, positron emission tomography (PET) scans of lipophilic statin users. Objective: To assess the association between statin therapy and risk of Alzheimer disease (AD) in a prospective cohort study with documented statin exposure and incident dementia. Methods: This is a prospective, cohort study of statin use and incident dementia and probable AD. A cohort of 2,356 cognitively intact persons, aged 65 and older, were randomly selected from a health maintenance. Hypercholesterolaemic individuals exposed to statin had a lower risk of overall dementia and Alzheimer's disease and related dementia in both sexes, and a lower risk of other types of dementia in women, than subjects who were not exposed to statins. Abstract. Volume 288, Issue 6. December 2020. Pages 689-698
OBJECTIVE: To determine if hypercholesterolemia or statin use are related to dementia risk in the oldest-old, people aged 90 years and over. BACKGROUND: Midlife hypercholesterolemia has been associated with increased dementia risk. Some studies, however, suggest that the association changes with age and high cholesterol may be associated with decreased dementia risk at very advanced ages . The results of two secondary prevention trials will be reported shortly. In spite of negative studies, the possibility remains that statin therapy may reduce risk of dementia and AD Objective Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia. The present study was conducted to assess whether statins can reduce the risk of dementia in these patients. Methods We used the data from National Health Insurance of Taiwan during 1996-2009. Standardized Incidence Ratios (SIRs) were calculated for LOD and subsequent dementia. specific group with a higher risk of dementia, such as patients with concurrent diabetes and hyperlipidemia. We aimed to examine the association between adherence to statins and the risk of dementia among patients with diabetes and comorbid hyperlipidemia. This was a retrospective study with a new user design A 2016 Cochrane systematic review identified 2 double-blind RCTs that evaluated statins for preventing cognitive decline and dementia in patients with either risk factors or a history of vascular disease. 1 The authors couldn't perform a meta-analysis because of heterogeneity
We hypothesize that statins might lower the risk of dementia after a concussion. We are conducting a population-based study linking multiple healthcare databases to test whether statin treatment is associated with a decreased risk of subsequent dementia among seniors following a concussion The research found that statins did not increase the risk of dementia. In fact these medications decreased it. So taking a statin may help both your heart and your mind. Previous research showed similar results. In a 2013 study, Johns Hopkins researchers looked at 41 studies that monitored 23,000 people for memory problems for up to 25 years Some people have concerns about statins increasing their risk of cancer or dementia or other neurocognitive problems. There is no research to suggest that statins increase these risks
Overall, the researchers linked high use of statins to a 15 percent lower risk of Alzheimer's in women and a 12 percent lower risk in men compared to those who had low use. Continued. Those who. Background: Statins (3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitors) reduce cardiovascular risk through mechanisms that might affect the development of dementia. Objective: To evaluate whether statin use is associated with a lower risk of dementia compared with never use of lipid-lowering agents (LLAs) A study appearing Monday in the journal Neurology found that statins dramatically reduced the risk of developing dementia and Alzheimer's disease among a group of subjects 60 years and older. It.
Questions remain, but so far, the use of statins solely for the prevention or treatment of dementia is not warranted. Dementia is the loss of cognitive function including memory, visuo-spacial and language skills, and executive function, sufficient to interfere with social or occupational activities. 1 The risk of dementia increases with age This paper reviews epidemiological and clinical trials data about whether statin use reduces the risk of Alzheimer's disease (AD). The available information has come in three waves. The initial, mostly cross-sectional observational reports suggested that statins might prevent dementia Statins are widely prescribed drugs to help lower cholesterol levels. The drug can significantly lower levels of cholesterol and as such reduce the risk of heart attacks and strokes. However, the drug can also affect the brain with some hypothesising it could increase a person's risk of dementia.Dr Tom Micklewright from Push Doctor spoke exclusively with Express.co.uk to offer his insights.
Statins are widely prescribed drugs to help lower cholesterol levels. The drug can significantly lower levels of cholesterol and as such reduce the risk of heart attacks and strokes. However, the drug can also affect the brain with some hypothesising it could increase a person's risk of dementia. Dr Tom Micklewright from Push Doctor spoke exclusively [ But cholesterol-lowering drugs inhibit neurotransmitter production which leads to impaired memory and other cognitive functions. (4) High total cholesterol actually reduces the risk of dementia in the elderly which is contrary to prevailing medical belief. (5) Statin Side Effects. Cholesterol-lowering statin drugs like Mevacor, Lipitor, and.
Lipophilic statin use linked to increased risk of dementia. In patients with mild cognitive impairment, taking lipophilic statins more than doubles their risk of developing dementia compared to those who do not take statins. According to research presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting, positron. Vascular risk factors, including high cholesterol levels, increase the risk for dementia due to Alzheimer disease and vascular dementia. Some observational studies have suggested an association. Lower death rates extended to those with other conditions such as dementia — individuals who have been excluded from previous studies. In secondary analyses, the team found that starting a statin was also significantly associated with a lower risk of cardiovascular events such as heart attacks and strokes Still, the adjusted risk for dementia seemed to go up by a third among statin users who at baseline placed in the lowest quartile for cognitive function, based on a composite test score, in the. Statins 'halve' the risk of dementia. Statins, which have saved millions of people from heart disease, may have an additional role in protecting the brain from dementia, researchers say. The so.
Most interestingly, in subjects aged 85 to 94, a high midlife total cholesterol level was associated with a reduced risk for marked cognitive decline. This finding is in contrast with both younger. The study, which analyzed 44,920 Swedish dementia patients from the Swedish Dementia Registry between 2008-2015, found users of statins had a 22% lower risk of all-cause death compared to matched. Report. Patients with mild cognitive impairment or normal cognition who used lipophilic statins were found to have more than double the risk of developing dementia compared to statin non-users. Statins, the widely prescribed drugs taken by millions of older men and women to help lower cholesterol levels and ward off heart attacks and strokes, may prevent dementia and memory loss with long-term use. They also do not appear to increase the risk of memory problems in the short term, a new analysis found