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DFSP CD99

A total of 29 DFSP and 5 GCF were analyzed by immunohistochemistry for expression of CD99. Twenty-three of 29 DFSP (79%) and 2 of 5 GCP (40%) expressed CD99. Comparison of CD99 and CD34 showed that the non-tumoral periphery of DFSP was less probable to be CD99 positive, but this finding was not statistically significant In DFSP, tumor cells in the superficial dermis, when present, were always CD99 negative. In contrast, DF cells in the superficial dermis always demonstrated strong CD99 positivity. CONCLUSIONS: DF strongly expresses CD99 in a diffuse pattern that may serve as evidence in distinction from DFSP Both components expressed CD34 and CD99, and lacked elastin. A review of the microscopic slides of the patient's previously excised DFSP revealed an identical lesion with surrounding NTF-like areas. CONCLUSION: While an association between NTF and fibromatosis has recently been reported, this is to our knowledge the first report of an. Dermatofibrosarcoma protuberans (DFSP) represents a locally aggressive mesenchymal neoplasm of skin and subcutis with characteristic clinicopathologic, immunohistochemical, and molecular findings. In addition to typical cases, morphologic variants such as pigmented, fibrosarcomatous, myofibroblastic, and granular cell DFSP have been described vimentin, and CD99 but negative for factor XIIIa, S-100, actin, and desmin.1,3 DFSP is thought to result from the reciprocal translocation t(17;22)(q22;q13), leading to fusion of the collagen, type I, alpha 1 and PDGFB genes that cause aberrant activation of the PDGF receptor and subsequent stimulation of cell growth.1,2,

Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive, slow‐growing, cutaneous tumor with a high local recurrence rate, but it rarely metastasizes. The histological morphology of DFSP can be divided into more than 10 subtypes. and negative for factor XIIIa, S‐100 protein, CD31, CD99, CD117, CK, ALK, and Desmin Synovial sarcomas, which are similar to DFSP, yield cellular smears with poorly cohesive clusters and dissociated bland-looking spindle cells 27 (Fig. 10A) that are positive for CD99 and focally positive for EMA and keratin (Fig. 10B) CD34+, ß-catenin+, CD99+, MIB1 50% R0 87 10 B M DFSP 46 Trunk On normal cutis 3.3 3 Primary n/a CD34+, PDGFR- alpha+, PDGFR- beta+. MIB1 5 - 10% R0 88 11 A F DFSP 50 Trunk On normal cutis 2.0 1 Primary n/a CD34+, MIB 2% R0 84 12 B F DFSP 89 Upper extremity On normal cutis 1.7 1 Perforator fla

  1. Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth. The tumor occurs in patients of all ages, with the highest frequency occurring between the second and the fifth decades of age. Genetically, DFSP is characterized by a reciprocal translocation t(17;22)(q22;q13), or more often, as a supernumerary ring chromosome.
  2. The initial diagnosis from an outside hospital was dermatofibrosarcoma protuberans (DFSP). The tumor was immunoreactive to cluster of differentiation (CD) 34 while negative for S100 protein, Melan-A, tyrosinase, MART-1 (melanocytic antigen recognized by cytotoxic T lymphocytes 1), human herpesvirus 8, cytokeratin, and smooth muscle actin (SMA)
  3. e which cytologic features permit a confident di-agnosis of DFSP in fine-needle aspiration (FNA) smears. Another objective was to compare FNA find-ings of DFSP with its fibrosarcomatous (high-grade) counterpart and with other spindle cell lesions which are differential diagnoses of DFSP
  4. CD99 has been used alone or in combination with factor XIIIa and CD34 to differentiate dermatofibroma from DFSP. [ 91 , 92 , 93 ] Leukocyte-specific protein 1 (LSP1) may aid in differentiation of dermatofibroma from DFSP
  5. CD99 is known to be an adhesion molecule on many tissue cells including RBCs. CD99 expression on RBCs is affected by presence or absence of Xg a. Anti-Xg a is uncommon, may either be RBC stimulated or naturally occurring, and has not been implicated in HTRs or HDFN. Rare antibodies to CD99 have been detected, and little is known about their.
  6. Both components expressed CD34 and CD99, and lacked elastin. A review of the microscopic slides of the patient's previously excised DFSP revealed an identical lesion with surrounding NTF-like areas. CONCLUSION:While an association between NTF and fibromatosis has recently been reported, this is to our knowledge the first report of an.
  7. CD99 has been used alone or in combination with factor XIIIa and CD34 to differentiate dermatofibroma from DFSP. [ 91 , 92 , 93 ] Leukocyte-specific protein 1 (LSP1) may aid in differentiation of.

CD99 expression in dermatofibrosarcoma protuberans and

Dermatofibrosarcoma protuberans (DFSP) is a relatively rare tumor. Estimates of the overall incidence of DFSP in the United States are 0.8 to 4.5 cases per million persons per year . In the United States, DFSP accounts for between 1 and 6 percent of all soft tissue sarcomas and 18 percent of all cutaneous soft tissue sarcomas Hemangiopericytoma Solitary Fibrous Tumor; Sheets of cells, usually no collagen separation: Bands of collagen separate cells: Staghorn vessels require Pathophysiology. Prevents cells from undergoing apoptosis. BCL2 overexpression increase lifespan of B cells; may maintain memory B cells, plasma cells and neurons by prolonging life span without cell division. May participate in ion channel formation and alteration of membrane permeability, necessary for initiation of apoptosis Recently, CD99 was shown to be diffusely expressed in DF thus providing another potential option for distinguishing the two tumors. Advanced techniques for distinguishing the tumors include fluorescent in situ hybridization (FISH) probe analysis for the t(17;22) translocation found in DFSP or array-based comparative genomic hybridization (CGH.

Dermatofibrosarcoma protuberans association with nuchal

FIBROSARCOMATOUS OR MFH CHANGE WITHIN DFSP Here, CD34 is positive. CD99 was also positive in this tumor (not shown) as was focal positivity for Bcl-2 (also not shown). Figure 1f. The whole tumor bed was grafted with a split thickness skin graft. The closest margin without a fascial boundry was 2.5 cm, a very adequate margin for a resection. DFSP is positive for vimentin, CD99 and CD34 but negative for FXIIIa [15]. Compared to 0-3 mitoses per 10 high-power fields (HPF) in the DFSP component, the sarcomatous component has 2-16 mitoses per 10 HPF [3]. The Bednar or pigmented variant, with melanin-containing cells is another infrequen The expression of CD99 and SMA(smooth muscle actin) is variable among lesions. DFSP has morphological variants that share similar clinical, histological, and immunohistochemical features. Myxoid DFSP (Bednar tumor), giant cell fibroblastoma, fibrosarcomatous DFSP, granular cell DFSP, and atrophic and palisading variants are among them

Myxoid dermatofibrosarcoma protuberans: clinicopathologic

  1. for CD34 differentiates DFSP from myxoid liposarcoma [4,16,17]. Our case showed diffuse strong positivity for CD34 and negative for all other markers like CK, DESMIN, S-100, SMA, P63, ER, Bcl2, CD99, TLE-1, STAT6, EMA (Figure 5). Surgical excision of the tumor remains the cornerstone for managin
  2. Even though both are strongly positive for CD34, superficial acral fibromyxoma is usually positive for CD99 and sometimes positive for EMA, For example, atrophic DFSP was initially diagnosed in a 6-year-old Korean girl who presented with a solitary congenital 4.0-cm plaque of CD34 diffusely positive spindle cell dermal proliferation. 43.
  3. For the fibrosarcomatous variant of Dermatofibrosarcoma protuberans a safety distance of 3.0-5.0 cm is required. Some authors recommend to take the fascia with you. Lymph node evacuation is usually not indicated, it only has to be considered in case of de-differentiated DFSP which have the ability to metastasize
  4. ent branching network of vessels, often with fibrin thrombi. Usu. Tender nodule on forearm. Spindle Cell Lipoma—Fat + bland spindle cells with a variably myxoid background

DFSP; vimentin, desmin, CD68 (PG-M1; Nichirei, Tokyo, Japan), MIC2, and EMA for AFH; and cyto-keratin, EMA, desmin, and synaptophysin for DSRCT. Both the study protocol and the informed consent form were approved by the institutional re-view board at each study site. All patients gave writ-ten informed consent for enrollment into the clinica The histopathological report showed DFSP with incomplete margins. The tumour cells are diffusely positive for CD34 but negative for pancytokeratin, desmin, SMA, S 100, CD117 and CD99 stains. Ki67 proliferative index is about 20-30%. DFSP was first reported by Hoffman et al almost nine decades ago

CD99 (20%), ETV4 (> 90%), WT1 (> 90%) NKX2.2: BCOR-rearranged sarcoma: Monomorphic or primitive appearing round to ovoid and occasionally spindled tumor cells arranged in intersecting fascicles or a patternless fashion: CD99 (80%), BCOR (> 90%), CCNB3 (90%) NKX2.2: Myxoid: Myxofibrosarcoma: Curvilinear blood vessels, pleomorphic cell CD99 also functions as a sensitive but unspecific marker of acute myeloid leukemia, myelosarcoma and acute lymphoblastic leukemia. A negative detection is available for Merkel cell carcinoma and DFSP. (see below) Cluster of differentiation. Literature. This section has been translated automatically Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth. The tumor occurs in patients of all ages, with the highest frequency occurring between the second and the fifth decades of age. Genetically, DFSP is characterized b Sanger sequencing. A diagnosis of fibrosarcomatous DFSP was rendered and the patient was in good status at a follow-up of 12months after the operation. Conclusions: We report a fibrosarcomatous DFSP with novel TNC-PDGFD fusion, which adds to the pathologic and genetic spectrum of PDGFD-rearranged DFSP Dermatofibrosarcoma protuberans (DFSP) 2. Giant cell fibroblastoma 3. Plexiform fibrohistiocytic tumor 4. Angiomatoid fibrous histiocytoma Desmin, CD99 positive in 50% o

The majority of these tumors stain strongly for CD34 and frequently for CD99 and CD10 , with focal expression of epithelial membrane antigen, nestin, desmin, and α-smooth muscle actin . The histologic differential diagnosis includes cellular fibroma, myxoid neurofibroma, superficial angiomyxoma, and DFSP. Treatmen Dermatofibrosarcoma Protuberans (DFSP) Neurofibroma . Dermal-based proliferation of typically bland, spindled to histiocytoid-appearing cells—can appear like a . blue haze . Tumors are grossly circumscribed but microscopically have irregular, often jagged borders . Collagen trapping . at periphery . Overlying epithelial . basilar inductio DFSP b t(17;22)(q22;q13) COL1A1-PDGFb CD34, vimentin Targeted therapy PDGFR a As estimated by Herzog [44] based on 2004 Surveillance Epidemiology and End Results data for the U.S. b Data for actual annual incidence unavailable, but estimated to be 1% of all sarcomas with an annual incidence of 50 activity for CD34 and CD99. A hypocellular area and a cystic area showed pleomorphic rhabdoid cells with immunoreactivity for desmin and myogenin. This is a report of a rare case of MSFT with rhabdomyosarcomatous differentiation and presents new histologic features of MSFT. Key Words: Solitary fibrous tumors; Malignant; Rhabdomyosarcom CD34 and CD99 positivity may also be observed in DFSP. 4,5 One recent study reported that NAB2-STAT6 fusion genes were specific to SFT, indicating that the study of these genes could be of use in overlap cases. 2 Nuclear immunostaining with STAT6 has high sensitivity and specificity, with positivity rates ranging from 91% in meningeal SFTs to.

Dermatofibrosarcoma protuberans (DFSP) is a locally aggressive but rarely metastasizing, fibroblastic neoplasm that typically presents as a nodular and multinodular cutaneous mass on the trunk and proximal extremities of young to middle-aged adults [1, 2].Classically, DFSP is composed of fairly uniform, mildly atypical spindle cells, often arranged in tight storiform, whorled, or cartwheel. E. Epidermal and adnexal tumors: AE1/AE3Cytoplasmic stain: SCC CK 5/6 (high mol wt): squamous differentiation, adnexal tumors CK 903: Poorly differentiated SC DFSP Monotonous spindle cells Storiform architecture in dermis and SubQ Honeycomb infiltration of fat CD34+ STRONG CD99, CD68, and SMA in tram track pattern) SLAM DDX. SCC - CK903 and CK5/6, p63, p40 Leiomyosarcoma - desmin+ and p40+ AFX - neg for high-mol wt keratin, p63,p40, S100, SOX10, desmin Melanoma - S100+, SOX-10 keratin!s100 ema!hmb45 cd45!mart-1 cd15!ttf1 vimentin!syn des!cga/cgb msa!cd99 antibodies applied to the study of small round-cell tumors monday, april 2, 1

Case DFSP is a mesenchymal tumor of intermediategrade malignant potential. Typically it presents during early or middle adult life.1,2 Pigmented DFSP (Bednar tumor) is a rare neoplasm, present in 1% to 5% of all cases of DFSP. CD99 expression in dermatofibrosarcoma protuberans and dermatofibroma. Dermatofibrosarcoma protuberans diagnosed by. DFSP from SFT, as both are CD34 + spindle cell neoplasms that also stain positive for CD99 and BCL-2. 2 . GRIA2 positivity also is seen in both SFT and DFSP. 7. However, differentiation can be made on morphologic grounds alone, as DFSP has ill-defined tumor borders with adnexal and fat entrapment and SFT tends to be more circumscribe Dermatofibrosarcoma protuberans (DFSP) is a malignant fibrohistiocytic tumor that appears exclusively on the skin. It is a low-grade malignant soft tissue tumor of subcutaneous tissues that has a propensity for local recurrence but seldom metastasizes. It may rarely occur on the head and neck accounting for less than one percent of total head and neck malignancies

Dermatofibrosarcoma Protuberans (DFSP) - PORTNotes

Rare myxoid dermatofibrosarcoma protuberans masquerading

Solitary fibrous tumor (SFT) is a malignant condition that exhibits different clinical behaviors ranging from low to high aggressive SFT. Even when surgery alone provides curation rates above 60%, recurrences do occur in a fraction of patients where surgery is unable to provide disease control. Among the systemic therapeutic options, antiangiogenic compounds have shown higher efficacy than. Cellular angiofibroma (CAF) is an uncommon benign mesenchymal tumour that occurs in both sexes, mainly in the genital region. Extragenital CAF is rare, with fewer than 10 cases reported to date (1-3) and, to the best of our knowledge, there has been no report of CAF occurring in the subungual or periungual region DFSP with fibrosarcomatous transformation - needs >5% of area - plump spindled cells - high nuclear grade - 7-10mits/10hpf 60% + CD99 . 20-40y Extremity Aponeurotic lesion . Clear cell sarcoma Nested growth Clear cyt SCATTERED GIANT CELLS LOW PLEOMORPHISM poor px. - variably sized and shaped spindle cells in storiform pattern + secondary components (not seen in DFSP): plasma cells, histiocytes (sometimes foamy), Touton giant cells, blood-filled spaces, hemosiderin - collagen trapping at periphery - Factor 13a+ - CD34- (but will highlight peripheral dermal dendrocytes attempting to wall it off Introducción. El dermatofibrosarcoma protuberans (DFSP) en un tumor mesenquimal con diferenciación fibroblástica y miofibroblástica localizado en la dermis y tejido celular subcutáneo de adultos jóvenes o de edad media 1,2, con un pico de incidencia en la cuarta década de la vida 3.Es un tumor de crecimiento lento y malignidad intermedia, localmente agresivo, que recidiva en más de un.

Lipofibromatosis-like neural tumour mainly occurs on the trunk and extremities of children and young adults. The main differential diagnoses of the lesion include DFSP, infantile fibrosarcoma, low-grade malignant peripheral nerve sheath tumour (MPNST), fibrous hamartoma of infancy and lipofibromatosis (Table I).DFSP rarely arises in children: patients younger than 16 years account for 6% of. DFSP ; Malignant counterpart; OPPOSITE staining pattern (POS: CD34, NEG: FXIIIa (factor 13a)) DFSP has spindle cells invading adipose tissue. t(17,22), fusing the collagen type 1 alpha gene (COL1A1 - chromosome 17) & PDGF-beta chain gene (chromosome 22). Elastofibroma General. Benign lesion, rarely recu Otro inmunomarcador presente en alrededor de 80% de los dfsp es cd99. El principal estudio inmunohistoquímico para el diagnóstico de este tumor es la marcación positiva para cd34 (tiñe de 50 a.

Page 1 1 IMMUNOHISTOCHEMICAL DIAGNOSIS OF POORLY-DIFFERENTIATED & MORPHOLOGICALLY-INDETERMINATE SKIN TUMORS AP119 Immunohistology in Dermatopathology - Part Cutis. 2017 November;100(5):282, 301-302. By Claire O. Dorfman, DO Christian W. Oram, DO Nektarios Lountzis, MD. Author and Disclosure Informatio dfsp的治疗以及头颈部dfsp详见其他专题。 (参见 隆突性皮肤纤维肉瘤的治疗 头颈部肉瘤,关于'硬纤维瘤和隆突性皮纤维肉瘤'一节 ) 流行病

A detailed discussion of each specific sarcoma subtype is beyond the scope of this chapter. We will instead present detailed information on four specific sarcomas, including Ewing's sarcomas (ES), dermatofibrosarcoma protuberans (DFSP), gastrointestinal stromal tumors (GISTs), and rhabdomyosarcomas (RMS) Accidently, the lesion location was scratched after surgery. by a cat 3 months ago. From then on, the mass grew rapidly. In summary, we report a rare patient with DFSP who The patient was in good health. There had been no similar presented clinically with a firm, nontender, flesh-colored, history of this appearance in his family Immunohistochemistry is a useful adjunct to the diagnosis of DFSP as long as it is understood that other dermal and subcutaneous spindle cell tumors are CD34+. 122 Typically, CD34 staining is uniformly and diffusely positive (Figures 24-29 and 24-30), but other markers have been reported to facilitate the diagnosis including CD99, D2-40, and.

Pediatric atrophic dermatofibrosarcoma protuberans - Liu

CD99 (MIC-2) Soft tissue tumor classification (not all that helpful) CD117 (c-kit) Gastrointestinal stromal tumors, mast cells, blasts Factor XIIIa Dermatofibroma vs. DFSP Fascin Hodgkin's cells, other reticulum cells FOSB Pseudomyogenic hemagioendothelioma FOXL1 Sex-cord Stromal tumor Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade malignant neoplasm that rarely presents in children. It is locally aggressive with a high rate of recurrence. We describe a boy who presented with a slow-growing nodule that was thought to be a pilar cyst. Histopathologic examination provided the diagnosis of dermatofibrosarcoma protuberans myxoid variant, which is one of the least. current DFSP from scar tissue, which is generally CD34 negative.30 Occasionally DFSP can show dedifferentiation with fibrosarcomatous areas. Several studies have shown partial or complete loss of CD34 staining in these are-as.25,31-33 Other potentially useful markers in the differen-tial diagnosis of DF and DFSP are HMGA1 and HMGA2 DFSP usually starts as a single slowly growing plaque on the trunk, and histologic findings show storiform fascicles of atypical spindle cells and involvement of the subcutaneous tissue in a pattern seems like a honeycomb, but in early stages, there might be low-cellularity and minimal atypia ETV4, WT1 positive (CD99 limited in extent) BCOR-rearranged sarcoma Monomorphic or primitive-appearing round to ovoid and occasionally spindled tumor cells arranged in intersecting fascicles or a patternless fashion BCOR positive, CD99 variable Poorly differentiated synovial sarcoma Overlapping nuclei, hemangiopericytoma-like blood vessel

Cytologic features of primary, recurrent, and metastatic

CD99: (+) in 10-60% of melanomas. Bcl-2: 60% (+) in primary melanoma, 76% (+) Pigmented DFSP (Bednar tumour) is a rare variant that can also be confused with melanoma due to the presence of pigmented cells. Histologically, DFSP is composed of monotonous spindle-shaped cells arranged in a storiform pattern . These cells have amophophilic. The DFSP component is composed of admixed CD34+ and FXIIIa+ dendritic cells arranged in a storiform pattern. Tumor cells are negative for actin, desmin, S-100, and cytokeratin. The Ki67 proliferation index is 1% in GCA areas and 3% in DFSP areas; Ki 67 stains mainly fibroblasts Myxoid DFSP • Myxoid NF • CD99, SMA variably bcl-2, S100, MSA • Recurrences common. Cells reminiscent of lipoblasts in zones where fat and fibroblastic component merge. Dermatofibrosarcoma Protuberans • Usually young adults • Recent case series (n=27) on distal extremities and acralsite

Dermatofibrosarcoma protuberans of the breast: A case repor

CD34 - GIST, angiosarcoma, solitary fibrous tumour/hemangiopericytoma, Kaposi sarcoma, DFSP, PASH. S-100 - neural marker, sensitive for malignant melanoma, Langerhans cells, clear cell sarcoma. Desmin - smooth muscle. MIB1 - proliferation. CD99 - immature T cells (thymus), small round cell tumours, synovial sarcoma, Merkel cell carcinoma. Some DFSP cases (8%) fail to demonstrate this translocation. 6 In such cases, the medication's potential therapeutic benefit may not occur. DFSP is unusual in the head and neck. In a recent review 2 of 1443 cases, 227 were noted in this region (16%). The present case most likely originated in the subcutaneous tissue and dermis overlying the.

CD99 is highly expressed in CD34 + bone marrow cells and in leukocytes, whatever the lineage, and it is a determinant in the orientation of immune response . As CD99 expression is usually lost in the dedifferentiated SFT (in the DD zones), it is probable that CD99 would act also as a tumor suppressor in the context of SFT Immunohistochemistry (IHC) is the use of antibody-based reagents for localization of specific epitopes in tissue sections. Over the past several decades, IHC has become a powerful tool to assist the surgical pathologist in many clinically critical settings. It is important to recognize that IHC has two components, each with its own strengths and weaknesses Non-lymphoid mesenchymal neoplasms of salivary gland origin are rare, accounting for 1.9-5% of major salivary gland tumors. We describe the clinico-pathologic features of 18 cases of mesenchymal neoplasms of the major salivary glands experienced at Asan Medical Center, Seoul, Korea, from 1998 to 2004. Mesenchymal neoplasms accounted for 3.4% of the total of 524 major salivary gland tumors

Soft Tissue Tumor Immunohistochemistry Update

Overview of Soft tissue Sarcoma Pathology Aspect Dr. Sorranart Muangsomboon. MAR 30, 2019. Ramathibodi hospita Some CD99-staining round cell sarcomas lacking an EWS (DFSP). After this potential fusion event was identified, re-review of an H&E slide from this case showed that this tumor was a spindle cell lesion with a storiform pattern similar to DFSP. However, it had been classified by central pathology review as an undifferentiated sarcoma prior. Academia.edu is a platform for academics to share research papers CD99 • Uniformly express CD99 with a characteristic membranous pattern in Ewing sarcoma • But it is not so specific • Positivity is seen in lymphomas, RMS, Mesothelioma, synovial sarcoma, solitary fibrous tumor, desmoplastic small round cell tumor etc. Bcl-2 • It is a family of protein involved in the apoptosis pathway in cell grown and. CD99, SEE MIC2 CD117 (c-kit) Gastrointestinal Stromal Tumors (GIST), Mast Cells Membrane and/or cytoplasmic CD138 Syndecan-1 Plasma Cells (also stains endothelial cells, celfibroblasts, keratinocytes, and normal hepatocytes) Cell Membrane, pre-B cell and plasma l ma rker, bu tis absen f om u e B cells. It is a selective marker for B cel

Skin - Nonmelanocytic tumors - Dermatofibrosarcoma

Video: CYTOPATHOLOGY Cytologic Features of Primary, Recurrent

DFSP Fibrous histiocytoma Giant cell fibroblastoma Juvenile xanthogranuloma Malignant giant cell tumor of tendon sheath Pleomorphic malignant fibrous histiocytoma CD99 and BCL2 are all positive but TLE1 is the bomb stain for SSs! 4. t(X;18) translocates SYT with SSX1 or SSX2 Plantar fibromatosis is a rare condition in which benign (non-cancerous) tumors called plantar fibromas grow on the bottom (plantar surface) of the foot. The plantar fascia is a long band of connective tissue that runs from the heel to the toes on the bottom of the foot. Plantar fibromas are firm masses that grow slowly along the plantar fascia. Immunohistochemistry is a technique for localizing and visualizing an antigen in a tissue section by using an antibody specific for the target antigen. The immunohistochemistry procedure consists of tissue preparation, antibody incubation, and a series of detection reactions. Technically, when the procedure is performed on cells (cell smears.

The pathologist's report contains the diagnosis (the identification of the particular subtype of sarcoma), as well as information about the size, shape, and appearance of a specimen, and information about the completeness of resection for surgical specimens. Molecular pathology is a growing field within pathology, which uses the genetic. Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Evidence (1

Dermatofibroma Workup: Imaging Studies, Procedures

a dermatofibrosarcoma protuberance (DFSP) and according to the second one as a hemangiopericytoma. In addition to recurrence, neglect on the part of patient, patient's fear, and Bcl-2, CD99, and vimentin [11]. The differential diagnosis is extensive including hemangiopericytoma, synovial sar Gastrointestinal stromal tumor (GIST) is a soft tissue tumor of the GI wall which is in the differential diagnosis of leiomyoma and fibromatosis. Most GISTs express c-kit (>95 %), CD34, and CD99 (Fig. 26.23). Sometimes weak positivity for S100, SMA, desmin, and synaptophysin (but not chromogranin) can also be found [135, 144, 145] CCSK has traditionally been considered an aggressive cancer with survival in the range of 20%. However, the addition of Adriamycin to chemotherapy regimens has improved survival to approximately 70%. Nonetheless, CCSK has the potential to recur late, more than ten years after diagnosis

Hong Kong Journal of Dermatology & VenereologyFibrous and Fibrohistiocytic Proliferations of the Skin

CD99 (MIC-2) Clasificacion de tumores de tejido blando: CD117 (c-kit) Tumores de estroma gastrointestinal, celulas masticas y blasticas: CD123: Tumores de celulas dendriticas plasmacitoides , celulas peludas: CD138: Celulas plasmaticas (varios tumores epiteliales) CD 163: Marcador histiocitico y monocitico: CDK4: Liposarcoma: CDX S100, EMA, MNF116, CD45, CD99 will also be useful to diagnose the less common lesions, as well as mimics of sarcomas such as carcinomas, lymphomas and melanomas. Probes for EWSR and SS18 should also be considered considering the significant proportion of undifferentiated round cell sarcomas seen in the study Superficial CD34 + fibroblastic tumour (SCFT) is an uncommon low-grade mesenchymal tumour of intermediate (borderline) malignancy. It occurs in middle-aged adults, with a slight male predilection, most frequently on the lower limbs, particularly the thighs (1-8) and focal CD99 positivity. S100, Desmin, SMA, CD117, CD31,andCD68werenegative.Ki67proliferationindexwas 2%. 3.Discussion GCA is a condition that represents the transitional stages within the HPC/SFT spectrum. It is accepted as a variant of HPC/SFT. It displays all features of a classic SFT but is identified by pseudovascular spaces lined by. To assess the use of anti-CD34 and anti-factor-XIII a antibodies for the differential diagnosis of dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP), we stained 40 DFs and 13 DFSPs. A significant population of dendritic and spindle cells was reactive with anti-factor-XIII a in 90% of DFs. In DFSP, most cases had very few or no reactive cells for this antiserum and reactivity was. CD34 em todos os casos, enquanto o EMA e o CD99 são positivos em muitos casos. Os resultados para proteína S100, proteína glial fibrilar ácida (GFAP), actina, desmina e queratina são tipicamente negativos no FAS(2,3). Por seu raro surgimento, o FAS é frequentemente con-fundido com outros tumores de tecidos moles mixoides