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Basaloid cells histology

Pathology Outlines - Trichilemmoma

Lung squamous cell carcinomas with basaloid histology

Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity Clin Cancer Res. 2014 Nov 15;20(22):5777-86. doi: 10.1158/1078-0432.CCR-14-0459. Epub 2014 Sep 4. Authors Christian Brambilla 1. Lung Squamous Cell Carcinomas with Basaloid Histology Represent a Specific Molecular Entity Christian Brambilla, Julien Laffaire, Sylvie Lantuejoul, Denis Moro-Sibilot, Hélène Mignotte, François Arbib, Anne-Claire Toffart, Fabien Petel, Pierre Hainaut, Sophie Rousseaux, Saadi Khochbin, Aurélien de Reyniès and Elisabeth Brambill Esophagus - Basaloid squamous cell carcinoma. Solid, cribriform or microcystic nests, strands, trabeculae or lobules of tumor cells (Histopathology 2000;36:331) Strands of tumor cells often connected to overlying squamous epitheliu

Lung Squamous Cell Carcinomas with Basaloid Histology

Pathology Outlines - Basaloid squamous cell carcinom

The proliferating cells have a generally rounded, basaloid appearance, and there may be varying degrees of melanin pigment deposition. Several histologic variants have been described, including hyperkeratotic, adenoid, clonal, and inflamed The histological hallmark of BSCC is its dimorphic pattern of presentation with a characteristic basal cell component associated with squamous component Basaloid squamous cell carcinoma (BSCC) surgically removed from sublingual location was xenotransplanted either subcutaneously or in the oral submucosa and the histology, ultrastructures, LDH isoenzyme pattern were investigated Basaloid squamous cell carcinoma, or BSCC, is a rare cancer most often found in the upper digestive and respiratory tracts. These types of carcinomas may develop in either gender at any age, but the condition seems more predominant in males around the age of 60 The basaloid squamous cell carcinoma (BSCC) is a variant of squamous cell carcinoma, having histologically distinctive features and appearing in the oral cavity, upper respiratory tract and esophagus. Histological hallmarks are the presence of a basaloid component in intimate association with squamous cell carcinoma. The basaloid component is characterized by tightly packed nests of cells with.

Basaloid squamous cell carcinoma (BSCC) of the colon is rarely found proximal to the anal canal. We report a case of an 81-year-old woman who was diagnosed with squamous cell carcinoma (SCC) of the lung without metastasis and BSCC of the sigmoid with differing histologic findings suggesting that these tumors were separate primary neoplasms Basaloid tumors are a common diagnostic problem in salivary gland pathology. However, delineating each of these tumor types is facilitated by an algorithmic approach incorporated by tumor border. Upon histology dark silhouettes corresponded to basaloid nodules in the dermis; within and outside the tumor nests melanin was present as dendritic melanocytes, clumps of free melanin, or melanin inside melanophages (Figure 1(d)). 3.2. Case

Histologic Mimics of Basal Cell Carcinoma Archives of

The basaloid appearing cells tend to stain basophilic deeply. The cells in the central portion may be polyhedral to spindle shaped; stellate reticulum-like areas are notably absent 11) . It is reported that tumors with follicular and acanthomatous histology have the highest and lowest recurrence rates, respectively 12) Biology of Human Tumors Lung Squamous Cell Carcinomas with Basaloid Histology Represent a Specific Molecular Entity Christian Brambilla 1, Julien Laffaire2, Sylvie Lantuejoul3, Denis Moro-Sibilot1,Helene Mignotte , Fran¸cois Arbib 1, Anne-Claire Toffart1, Fabien Petel2, Pierre Hainaut4, Sophie Rousseaux5, Saadi Khochbin5, Aurelien de Reynies2, and Elisabeth Brambilla histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage Lianjun Di1, Kuang-I Fu1,2, Xinglong Wu3, Xuemei Liu1, Rui Xie1, Rong Zhu1 and Biguang Tuo1* Abstract Background: Basaloid squamous cell carcinoma of the esophagus (BSCCE) is generally detected at advanced stag

Which histologic findings are characteristic of basal cell

Histological Features (Histology) (For professionals) Basaloid cells are small and uniform in aspect with a relatively voluminous and hyperchromatic nucleus compared with little cytoplasm, as in the stratum basale in normal skin{Kirkham, 1997}. In edematous areas, intercellular bridges can be seen {Andrade, 1959} Histologically they are characterised by superficial collections of atypical basaloid cells projecting from the epidermis or from the sides of adnexal structures such as hair follicles or eccrine ducts. Due to the 2 dimensional processing of histology specimens most superficial BCCs appear multifocal but recent studies using digital imaging. Histologically, it is a large, circumscribed basaloid tumor that shows less follicular differentiation than trichoepithelioma . 1 Merkel cells, identified by CK 20, are frequently seen in trichoblastoma compared with BCC. 7 Cutaneous lymphadenoma is a rare variant of trichoblastoma that is composed of multiple rounded lobules of basaloid cells. Pilomatrixoma : Histology. At low magnification, pilomatrixoma has a biphasic appearance consisting of solid blue areas of basaloid cells and eosinophilic areas of ghost cells. Basaloid component predominates in early lesions where as ghost cells make up the bulk of mature lesions. There is usually a sharp demarcation between the two components. MP/H Rules/Histology--Skin: What histology code and MP/H Rule apply to a skin primary with the final diagnosis, Basaloid carcinoma with squamous and neuroendocrine differentiation? See Discussion. Discussion . The patient had an upper arm shave biopsy with final diagnosis of basaloid carcinoma with squamous and neuroendocrine differentiation

Basaloid Squamous Cell Carcinoma - Tonsil. Advertisement. Tweets by @WebPathology The mixed warty-basaloid variant is usually characterized by a warty appearance superficially, and basaloid histology deeper. Verrucous carcinoma (VC) is a distinct variant of well-differentiated P-SCC, which presents as a slow-growing warty tumor

The cells of basaloid carcinoma are positive for cytokeratin and negative for neuroendocrine markers. In some tumors basaloid pattern is mixed with patterns consistent with adenocarcinoma, large cell carcinoma, or squamous cell carcinoma. The World Health Organization classifies basaloid carcioma under large cell carcinomas Basal cell carcinoma (BCC) is the prototypical basaloid tumour of the skin, but may show various patterns simulating other cutaneous tumours, particularly squamous cell carcinoma and trichoepithelioma (TE). Other challenges are presented by BCC with marked pleomorphism, glandular differentiation, neuroendocrine differentiation, clear cells and sarcomatoid change Basaloid squamous cell carcinoma. 3. Verrucous carcinoma. indolent lesion characterized by an endophytic papillary or verruciform surface, a pushing invasive front and a high degree of differentiation with little cytological atypia. 4. The photomicrograph shows the invagination of epithelium, the invasive downward growth of the epithelium, and. Basaloid squamous cell carcinoma (BSCC) was first described in 1986 by Wain et al. [] in the tongue, larynx and hypopharynx as a distinctive histological variant of squamous cell carcinoma with aggressive behaviour.Upper aerodigestive tract is the most common site of origin of this tumour in the head and neck [2, 3], especially epiglottis, hypopharynx (piriform sinus) and base of the tongue [4. of basaloid cells forming buds and strands in connection wi th the lower surface of the epidermis. A relative increase in the number of melanocytes has been reported [2]. This, however, is not appar­ ent in the histologic sections..

Pilomatricoma pathology DermNet N

In this type, the squamous cells outnumber the basaloid cells. Most eddies appear to show at least one of the morphological features of intraepidermal hairr follicle structures [2]. Squamous eddies may be confused with horn pearls of squamous cell carcinoma, but can be differentiated from them by their large number, small size, and circumscription The feature which most distinguishes basaloid carcinoma from other squamous cell tumours of the anal canal is the presence of palisading at the periphery oftheclumpsoftumourcells (Figs. 1 and 2). One feature of the histology unlike basal cell carcinoma was the presence of a varying amount ofeosinophilicnecrosis withintheclumpscftumour cells. Malignant neoplasm composed of basaloid cells arising putatively from prostatic basal cells. Very rare, only <75 cases reported. Wide age range (30's - 80's), but majority occurs in older men. Most commonly presents with obstructive urinary symptoms. Normal serum PSA level Squamous cell carcinoma of the head and neck, abbreviated head and neck SCC, is a common malignant epithelium neoplasm of the head and neck.. This is an overview article that deals only with the usual squamous cell carcinoma of the head and neck, or squamous cell carcinoma of the head and neck not otherwise specified (abbreviated SCC of the H&N NOS)..

In a previous study, we described an elevated prevalence of human papillomavirus (HPV) in two specific types of squamous cell carcinoma of the vulva designated basaloid carcinoma (BC) and warty carcinoma (WC) compared with the conventional type of keratinizing squamous cell carcinoma (KSC). To determine whether there were other differences in their clinical presentation or behavior, we. Basal cell carcinoma of oral cavity. 1. MALIGNANT TUMORS OF THE EPITHELIAL TISSUE ORIGIN Basal Cell Carcinoma (Basal cell epithelioma, BCC, rodent ulcer) 2. Introduction The most common malignancy in humans Develops most frequently on the exposed surfaces of the skin,the face and the scalp in middle-aged or elderly persons People with fair. Histology confirmed the case as infiltrated BCC with ulceration but unlike infiltrated BCC where palisading of basaloid cells is mostly lost our case demonstrated significant palisading. There was also no demonstrable local or distant metastasis in our case, unlike most of the giant BCCs Basaloid squamous cell carcinoma (BSCC) is an aggressive, but rare variant of squamous cell carcinoma (SCC) with atypical basaloid cells. 1,2 BSCC is found in the mucocutaneous and anogenital regions and is not routinely observed as a primary skin cancer. 1 To date, seven cases of primary cutaneous BSCC outside the upper aerodigestive tract and mucosal genital regions have been reported. 2.

B. Basal cell adenoma. Basal cell adenomas typically present as well-circumscribed nodules that are often encapsulated. On smear preparations, the neoplastic population is composed of basaloid cells characterized by round to ovoid nuclei, smooth nuclear contours, granular chromatin distribution, and scant amounts of cytoplasm arranged in nests and trabeculae, sometimes with vague peripheral. Alvarez-Cañas MC, Fernández FA, Rodilla IG, Val-Bernal JF. Perianal basal cell carcinoma: a comparative histologic, immunohistochemical, and flow cytometric study with basaloid carcinoma of the anus. Am J Dermatopathol. 1996 Aug;18(4):371-9. Graham RP, Arnold CA, Naini BV, Lam-Himlin DM. Basaloid Squamous Cell Carcinoma of the Anus Revisited

Basal cell carcinoma - Libre Patholog

The cells were small basaloid, having scant cyanophilic cytoplasm, indistinct cell borders, and round hyperchromatic nuclei showing coarse granular chromatin and inconspicuous nucleoli [Figure 1c]. Many epithelial fragments showed cells embedded in metachromatic basement membrane-like matrix with numerous fibroblasts and melanophages Basaloid squamous cell carcinoma of the upper aerodigestive tract is a rare, morphologically distinct variant of squamous cell carcinoma that is thought to be clinically aggressive. The histologic features are distinct from, but often confused with, those of human papillomavirus-related oropharyngeal nonkeratinizing squamous cell carcinoma The basaloid appearing cells tend to stain basophilic deeply. The cells in the central portion may be polyhedral to spindle shaped; stellate reticulum-like areas are notably absent 11) . It is reported that tumors with follicular and acanthomatous histology have the highest and lowest recurrence rates, respectively 12)

Global Dermatology » Histological Features (Histology

Nodular basal cell carcinomas can enlarge and ulcerate, but growth is seen over years rather than weeks. 5 Histology characteristically will show tumor islands composed of basaloid cells with peripheral palisading and clefting between the tumor islands and the stroma Presented by William Westra, M.D. and prepared by Shien Micchelli, M.D. Case 5: 70 year-old man with a large hypopharyngeal mass They are more developed in male dogs. Histologically, they appear as discrete lobules composed of an outer layer of small basaloid cells surrounding larger, polygonal cells with abundant eosinophilic (pink) cytoplasm (resembling hepatocytes). These glands are of clinical importance as hepatoid gland adenomas (benign tumors) are common All 12 cases exhibited prominent basaloid histology. Four were purely solid, 7 exhibited a cribriform pattern reminiscent of salivary ACC, and 1 had a mixed pattern. The MYB rearrangement was detected in 2 (29%) of 7 ACC-like carcinomas but in none (0%) of the 5 PBCCs with a prominent solid pattern Basaloid squamous cell carcinoma Basaloid squamous cell carcinoma is a high-grade variant of SCC composed of both basaloid and squamous components (Barnes et al., 2005). It is an aggressive, rapidly growing tumor characterized by an advanced stage at the time of diagnosis (cervical lymph node metastases) and a poor prognosis

Basaloid cell definition of basaloid cell by Medical

Week 277: Case 1. This 50 year-old female patient with a history of squamous cell carcinoma of the anus, status post chemoradiation presented with worsening discomfort. She had persistent pain and an enlarged mass on PET scan for which she underwent an abdominal perineal resection. images/073106PI1a.jpg Basaloid squamous cell carcinoma must be distinguished from basal cell carcinoma, metastatic small cell carcinoma, and Merkel cell carcinoma. Basal cell carcinoma (BCC) is a common skin cancer identified on sun-exposed areas but is rarely seen on the vulva, comprising approximately 5 % of vulvar malignancies (Fig. 10.16 ) [ 89 ] 5.6 Large Cell Carcinoma Large cell carcinoma of the lung has histology that lacks glandular or squamous differentiation by light microscopy and has no cytological features of small cell carcinoma. Large cell carcinoma is a diagnosis of exclusion and includes all poorly differentiated Non-Small Cell Carcinomas (NSLC) that cannot be classified further by routine light microscopy The cell block was helpful in this case, as it showed primitive appearing basaloid type cells arranged in nests, with a palisading border. Immunohistochemistry performed on the cell block showed that the malignant appearing cells were positive for AE1/3, MNF116, P63, and P40

Endoscopic features and associated histology of an

The histology of 36 benign and four proliferative Brenner tumors is reviewed, and the ultrastructural The basaloid cells (those in contact with the basal lam- ina) were smaller than the central polygonal cells and contained many free ribosomes and occasional smal Histology The histopathological evaluation of the tumours (Table 1) revealed 11 nodular, 5 superficial, 4 infiltrative, 1 pigmented and 1 adenoid BCC. The nodular types of BCC showed the typical tumour cell aggregates of atypical basaloid cells organized in nodules or lobules. The peripheral palisading which is caused b Cytology reveals clusters of basaloid cells with some of them showing retention of peripheral palisading, as in the histology. Basaloid cells are similar to normal basal keratinocytes in appearance but are larger and more deeply basophilic. They are uniform in size, elongated and the nucleus is central oval, intensely basophilic and occupies.

Fine-Needle Aspiration Cytology of Cellular Basaloid

  1. Histology: Tumor consists of basaloid (= roundish, sligtly paler, regular with relatively large nuclei) keratinocytes). Horn cysts with abrupt keratinization are often present (basaloid cells of the tumor suddenly mature into regular keratin lamellae. These lamellae have no parakeratosis and in HE staining are usually slightly bluish
  2. Different histological variants of sebaceous carcinoma are recognised, the most important being the basaloid, spindle cell, squamoid and dedifferentiated (pleomorphic) variants. Basaloid sebaceous carcinoma is composed of small basaloid cells, with palisading at the periphery of the epithelial lobules, and inconspicuous sebocytes
  3. Basal cell carcinomas (BCCs) are a group of tumours comprising masses of basaloid cells with hyperchromatic nuclei and scanty cytoplasm, resembling cells of the basal layer of the epidermis and of follicular epithelium. The tumour has a blue cell appearance. Overview of evidence (non-systematic literature review) [edit source
  4. Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity 10.1158/1078-0432.CCR-14-0459. Epub 2014 Sep 4.International audiencePURPOSE: The basaloid carcinoma (pure) and the (mixed) basaloid variant of lung squamous cell carcinoma (SCC) have a dismal prognosis but their underlying specific molecular.
  5. How these inflammatory cells (or the soluble mediators they produce) elicit squamous differentiation in a preponderantly basaloid neoplasm is an unknown biologic phenomenon. The inflammatory stimulus of irritated seborrheic keratoses clinically is often spontaneous, is composed mainly of lymphocytes, and may represent a phenomenon analogous to.
  6. Case 18 Malignant Melanoma, histology: Malignant large cells, containing brown melanin pigment in: pin. DERMATOLOGY MINI ATLAS Joseph Revised November ppt download Case 19 B A Basal Cell Carcinoma, histology: Basaloid (blue) cells (A: pin. Unit Viral infections: Fungal infections: 1, tinea capiti
  7. The basaloid cell population is most probably myoepithelial in origin. Histology (H&E): The epithelial component of this tumor is usually basaloid, very monomorphous, not at all suggesting malignancy! The histology is a peculiar, well known lesion, often accompanied by perineural invasion

Basaloid skin tumours: Mimics of basal cell carcinom

  1. Abstract. Top. We report a case of a 33-year old woman with a squamous-cell carcinoma of the rectum, of the basaloid subtype, infiltrating the uterus. The pathologic data and imaging findings that document the presence of the primary tumor of the rectum are presented in detail. Basaloid tumor is a histologic subtype of squamous-cell carcinoma.
  2. as around the tumor nests on Periodic acid Schiff staining (magnification ×200). The histology is compatible with basal cell adenoma with cystic change. MR imaging showed a 2 × 2 × 1.5-cm, well-marginated mass lesion at the medial portion of deep lobe of left parotid.
  3. Background. Basaloid squamous cell carcinoma of the esophagus (BSCCE) is an extremely rare tumor, accounting for only 0.068-4.0% of total esophageal malignant tumors [1-3].Advanced BSCCE has a poorer prognosis compared to typical squamous cell carcinoma, but the prognosis of early BSCCE does not differ significantly from that of typical squamous cell carcinoma [4-6]
  4. ent basal cell layer and distinct basement membrane-like structure and no myxo-chondroid stromal component as seen in pleomorphic adenomas. Three cellular patterns occur: solid, trabe-cular-tubular, and membranous
  5. In unclear cases, the most useful immunohistochemistry marker appears to be MOC-31, which essentially always stains metatypical basal-cell carcinomas but not basaloid squamous-cell carcinomas. UEA-1 appears to be the second most useful marker, staining almost all basaloid squamous-cell carcinomas but only a few metatypical basal-cell carcinomas
  6. antly affecting middle-aged and fair-skinned individuals [].Histopathologically, BCCs are composed of islands or nests of basaloid cells, with palisading of the cells at the periphery and a haphazard arrangement of those in the centers of the islands
  7. Morphology & Grade ICD-O-3 Morphology Codes. If the diagnostic term in the pathology report is not in the list below, be sure to consult your ICD-O manual.. Small cell lung cancers include ICD-O morphology codes M-80413, M-80423, M-80433, M-80443, and M-80453. Small cell carcinoma is also called oat cell, round cell, reserve cell, or small cell intermediate cell carcinoma
Pathology Outlines - Penile intraepithelial neoplasia

Vocal cord nodule/polyp. Vocal cord nodule/polyp, also known as singer's nodules, is a non-neoplastic lesion secondary to inflammation or trauma to the true vocal cord. There are four histologic subtypes: edematous-myxoid, fibrous, vascular, and hyaline. However, most polyps show overlap of these features as seen in the photomicrograph, which. Sharply demarcated plaques or papules; histology shows basaloid cell acanthosis and no papillomatosis Read the full article. Get immediate access, anytime, anywhere By definition the basaloid component comprises greater than 50% of the tumor. This is important in distinguishing sebaceoma from sebaceous adenoma in which basaloid cells represent less than 50% of the tumor. Figure 1. Low power view of a sebaceoma. It is a well circumscribed, symmetrical basaloid tumor containing scattered sebocytes The cells were small basaloid, having scant cyanophilic cytoplasm, indistinct cell borders, and round hyperchromatic nuclei showing coarse granular chromatin and inconspicuous nucleoli c. Many epithelial fragments showed cells embedded in metachromatic basement membrane-like matrix with numerous fibroblasts and melanophages Basaloid squamous cell carcinomas (BSCCs) in oral lesions are extremely rare, and the histology is not well understood. Histologically, they are often similar to conventional squamous cell carcinoma (SCC). The present study was designed with an aim to distinguish BSCC from SCC using claudin‑4, occludin, SRY‑box 2 (SOX2) and proliferating cell nuclear antigen (PCNA) immunoreactivities and.

Nodular Basal Cell Carcinoma - an overview ScienceDirect

Fig. 1 Basaloid cell component of the tumor: small, crowded cells with scant cytoplasm arrange in solid nest. Hematoxylin and eosin stain, 9200 - Basaloid squamous cell carcinoma of the esophagu Histological appearances of the basaloid squamous carcinoma component. (A) The basaloid cells with hyperchromatic and round nuclei exhibit a variety of growth patterns. They are arranged in variable-sized lobules, nests and cords (hematoxylin-eosin stain, ×100). (B) The basaloid cells show peripheral palisading (hematoxylin-eosin stain, ×100) Basal cell carcinoma (BCC) pattern, composed of variably sized solid nests, cords, or trabeculae with peripheral palisading of basaloid cells, may be associated with extensive central necrosis. Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR ( 35 ) ( Figure 2A ) Human papillomavirus (HPV) is recognized as the key risk factor for a distinct subset of oropharyngeal squamous cell carcinoma. P16 is a reliable, sensitive surrogate marker for HPV and confers a positive prognostic advantage. Basaloid differentiation on hematoxylin and eosin (H&E) staining is anecdotally noted by some pathologists to be associated with p16 positivity

Basal cell carcinoma pathology | DermNet NZ

The other type you may need to recognize is the basaloid type, in which the tumor grows in a solid nest of blue cells. The basaloid type carries the worst prognosis (20% 5-year survival rate, vs. 70% 5-year survival rate for non-basaloid types). Other types include the comedo, sclerosing, and tubular patterns (probably not as important to. Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma (SCC) that may arise in a variety of head and neck locations, including the oropharynx, hypopharynx, and larynx. 1 It is estimated that 2% of all head and neck SCCs and 5% of all node-positive SCCs are classified as BSCC. 2,3 Compared with those with SCC, patients with head and neck BSCC more often have. The tumor is composed of irregular nests of basaloid cells, resembling basal cell carcinoma. Trichblastoma differs from basal cell carcinoma with its variable stromal condensation and pilar differentiation . Additionally, basal cell carcinoma is a basaloid neoplasm that originates from the epidermis TransgloTTic Basaloid squamous cell carcinoma of The larynx 231 Discussion Because of the biphasic histology of basaloid squamous cell carcinoma, there is a potential for misdiagnosis in biopsies that are not fully representative. When the basaloid component is noted, the tumor must be differentiated from adenoid cysti

Trichoepithelioma is a rare neoplasm originating from basal cells in hair follicles. It can present as a solitary nodule or multiple nodules with familial or non-familial inheritance pattern. It rarely presents as a solitary nodule on the upper eyelid, though this is exceedingly rare. It is often confused basal cell carcinoma, though modern immunohistochemistry and pathology have improved. Basaloid Squamous Cell Carcinoma of Lung is a rare and poorly-differentiated histological variant of pulmonary squamous cell carcinoma. This differentiation is based on the appearance of cells when observed under a microscope by a pathologist

CYLD GeneticTesting for Brooke-Spiegler Syndrome, Familial

Seborrheic Keratosis - an overview ScienceDirect Topic

basaloid carcinoma: 1. a type of squamous cell carcinoma of the anus originating in tissues arising from, or in remnants of, the cloaca. 2. in oncology, anal cancer arising proximal to the pectinate line. Synonym(s): basaloid carcinoma , cuboidal carcinoma [cloaca + -genic Histology and cell components of salivary malignancies. Histology diversity due to: - A salivary malignancy with basaloid cells. - Basaloid SCC arises from the excretory ducts of intraoral minor salivary glands - Most frequent minor salivary gland carcinoma in some countrie Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. Int J Urol . 2015 Feb. 22 (2):222-5. [Medline]

Pathology Atlas: Vulva | GLOWMPathology Outlines - Inverted follicular keratosis

Figure 22 Trichoblastoma. (A) Scanning magnification of a basaloid lobule in the deep dermis. (B) Higher magnification of basaloid lobules without stromal retraction. Figure 23 Trichilemmocarcinoma. Proliferation of invasive atypical pale cells resembles clear cell squamous cell carcinoma. Continue reading here: Normal Histology. Was this. REGISTRATION TO STEP 2 ELIGIBILITY CRITERIA: Patients must have histologically proven stage IIB (T3N0M0 only), IIIA (T2N1M0), IIIB (T4N0M0), or IIIC (T3N1M0, T4N1M0) invasive squamous cell carcinoma of the anus or anorectum, according to the AJCC 8th edition; this may include tumors of non-keratinizing histology such as basaloid, transitional. Patient must have histologically proven T1-2N0M0 invasive anal canal or anal margin squamous cell carcinoma with tumors measuring =< 4 cm within 4 weeks prior to randomization. This may include tumors of non-keratinizing histology such as basaloid, transitional cell or cloacogenic histology Basaloid‐squamous carcinoma Basaloid‐squamous carcinoma Tsang, W.Y.M.; Chan, J.K.C. 1992-09-01 00:00:00 Sir: In a recent paper by Tsang et al.â , the authors demonstrated the many morphological similarities between basaloid-squamous carcinoma of the upper aerodigestive tract and so-called adenoid cystic carcinoma of the oesophagus, suggesting that many of the latter tumours are actually.